Reactive Nitrogen Species

High Quality Content by WIKIPEDIA articles! Reactive nitrogen species (RNS) are a family of antimicrobial molecules derived from nitric oxide (NO) and superoxide (O2-) produced via the enzymatic activity of inducible nitric oxide synthase 2 (NOS2) and NADPH oxidase respectively. NOS2 is expressed primarily in macrophages after induction by cytokines and microbial products, notably interferon-gamma (IFN-?) and lipopolysaccharide (LPS).